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Ongoing MaHPIC Research Projects

1880 drawings by Laveran of malaria parasites
The MaHPIC team is composed of a united group of interdisciplinary, global, scientific thinkers, interested in the big picture of host-pathogen interactions and the possibilities afforded by systems biology approaches.   We seek to understand malarial disease more thoroughly, specifically how recrudescence, relapse, host susceptibility, and co-infections in our host-pathogen systems affect the various clinical scenarios as they relate to the human infection.   To accomplish these goals, the MaHPIC has been implementing several different experiments, each of which is driven by a strategic infection, monitoring, collection, analysis, and integration of large, unique, omic data sets in combination with the clinical parameters of disease.   These unprecedented data sets may prove useful for the identification of biomarkers and this would be an important translational outcome.
The central unifying hypothesis of this project is: 
“Non-Human Primate host interactions with Plasmodium pathogens as model systems will provide insights into mechanisms as well as indicators for human malarial disease conditions”. 

Note: The image above is a detail from a drawing of malaria parasites done by Charles Louis Alphonse Laveran (1845-1922). Dr. Laveran was the Nobel Prize-winning French physician who discovered
Plasmodia and identified the parasites as the cause of malaria.