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Experimental Approach

Interactions between MaHPIC Cores depicted in a diagram

The image above depicts the functions and interactions ofthe 8 MaHPIC Teams 

The complex nature of the Plasmodiumlife cycle and the many interactions that the parasite has with its host makes studying the disease process very difficult. 

The MaHPIC provides aninnovative omics approach to malaria research. Using the newest experimental and computational tools available, MaHPIC researchers are able to analyze enormous amounts of information, looking at changes in the host and parasite during an infection.  The MaHPICTeams are investigatingfor changes in gene activity, protein expression, metabolism, and lipid compositionusing cutting-edge omics technologies.  The host's immune reaction to the parasites is also monitored for investigating themalaria immune profiling.  

MaHPIC experiments include longitudinal studies of Plasmodium infections (or uninfected controls) in non-human primates, and clinical and metabolomics studies of human samples.  The MaHPIC strategy is to collect physical specimens from non-human primates (NHPs) over the course of an experiment. The clinical parameters of infected animals and uninfected controls are monitored daily for about 100 days. During the experiment, NHPs receive antimalarial treatments to mimic relapse or recrudescence depending on the infecting species. Animals receive a curative treatment at the end of the experiment. At specific milestones during disease progression, blood and bone marrow samples are collected and analyzed by the MaHPIC teams and a diverse set of data and metadata are produced. 

The large amounts of information generated by the Teams are analyzed by MaHPIC scientists trained to analyze information and develop models that can explain the how, when, where, why of the infection.