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MaHPIC Research

PlasmoDB
metabolomic data set

The MaHPIC project is a systems biology investigation of malaria in non-human primate infections and clinical samples from humans around the world. MaHPIC scientists are examining malaria infection in non-human primate models that are susceptible or refractory to a given parasite, or that display relapse or recrudescence (blood infections from the activation of dormant liver-stage parasites called hypnozoites, or a rise in a low level of parasites already present in the blood, respectively).  Three nonhuman primate malaria species are being studied: P. coatneyi to model P. falciparum, P. cynomolgi to model P. vivax, and P. knowlesi, a monkey malaria species that has been causing illness and cases of death in humans in Southeast Asia. The MaHPIC project also includes New World owl monkeys (Aotus), which are susceptible to infection by the most predominant human malaria species, Plasmodium falciparum and P. vivax.  At the same time, the center collaborates with scientists in malaria endemic countries from around the world who are working in clinics and laboratories aiming to develop malaria vaccines, new therapies and diagnostics. In the context of larger ongoing studies in South America, Asia, Africa, and the Pacific, MaHPIC is analyzing blood samples to establish molecular signatures for different types of infections and disease states.