Introduction to the MaHPIC Research Teams
Experimental and analytical research teams comprise the core infrastructure of the MaHPIC.
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Malaria Team – designs and implements experimental plans involving infection of non-human primates and establishes collaborations and plans for the comparative analysis of clinical samples from human infections from several parts of the world that are endemic for malaria. |
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Immune Profiling Team – determines the frequency and functionality of the white blood cells in the peripheral blood and progenitors in the bone marrow as well as the levels of proinflammatory mediators in plasma in the course of malaria infections of non-human primates. |
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Functional Genomics Team – develops gene expression profiles representing host-parasite interactions from blood and bone marrow samples in the course of malaria infections of non-human primates. |
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Proteomics Team – develops detailed proteomic profiles of infected red blood cells and infected RBC membrane fractions in the course of malaria infections of non-human primates. |
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Metabolomics Team – provides detailed metabolomics data for plasma and associated cellular fractions collected in the course of non-human primate infections and from several collaborations involving human plasma or serum samples from malaria endemic areas of the world. |
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Lipidomics Team – uses targeted and untargeted/qualitative approaches to investigate lipids and biochemical responses associated with lipids as a result of malaria infection in the infected red blood cell and bone marrow in the course of malaria infections of non-human primates. |
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Informatics Core – standardizes, warehouses, maps and integrates the data generated by the experimental cores, including non-human primate infections and human data for further analysis and distribution to the project and scientific community. |
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Mathematical Modeling and Computational Analysis Team – integrates the datasets generated by the experimental cores into static and dynamic models, using mathematical and graphical approaches that capture host-pathogen interactions during infection for each combination of host and pathogen species. |
