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About the Functional Genomics Team

reference genomes of several malaria parasite (plasmodium) species

The Functional Genomics Team generates transcriptional profiles across the course of malaria infection of non-human primates. RNA is prepared from bone marrow or whole blood samples and cDNA libraries are generated for sequencing on an Illumina HiSeq2000 at the Yerkes National Primate Research Center. This team works closely with the Informatics team to align the short sequence reads in parallel to the relevant host non-human primate and Plasmodium parasite genomes, and ensure that they are appropriately archived and annotated. One of the keys to functional genomic analysis is appropriate normalization, so much effort is devoted to quantitative processing of RNASeq profiles, along with other ‘omic datasets provided by the various MaHPIC experimental teams. The Functional Genomics Team also works closely with the Computational Modeling Team to ensure that the systems biology modeling is integrative, innovative, and up-to-date.  The Genomics Team of the Yerkes National Primate Research Center of Emory University provides genomic DNA and RNAseq services for MaHPIC. 

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