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Frances Eun-Hyung Lee, PhD

Frances Lee


Assistant Professor, Medicine
Division of Pulmonary, Allergy, and Critical Care Medicine
Emory University

Role in MaHPIC

Investigator, Metabolomics Team

Dr. Lee works on metabolomics, bioinformatics and systems biology, and combines such methodological and computational developments with important biomedical questions, especially in human immunology.  Through large scale data integration and network modeling, Dr. Lee helped define important transcriptomic programs for vaccine induced antibody response.  Such work represents a first step to bring omics data into quantitative modeling of human immune response.  Metabolomics data from high resolution mass spectrometry provides detailed chemical information resulted from gene activities, environmental exposure, pathobiology, host-pathogen interaction and pharmacological interventions.  The effective mining of metabolomics data thus presents fascinating possibilities to understand and monitor health and diseases.  Dr. Lee has brought genome-scale metabolic models into the field of high throughput metabolomics, and developed cutting-edge algorithms for analyzing metabolomic data.  These works have demonstrated great potential to produce mechanistic insights.  Dr. Lee is working collaboratively with other MaHPIC investigators to explore the metabolomic changes that occur within the host and parasite during malaria infection.  She is applying her knowledge of systems biology and metabolomics to understand this complex interplay.



Phone: 404-712-2988