Welcome to the MaHPIC website!
The MaHPIC team is excited to share this website for the benefit of scientists, teachers, students, journalists and others interested in gaining a deeper understanding of systems biology and malaria, a disease that brings illness to several hundred million people each year in about 100 countries worldwide.
The MaHPIC represents a team of interdisciplinary, global, scientific thinkers interested in the big picture of host-pathogen interactions and the possibilities afforded by systems biology approaches. We seek to understand malarial disease more thoroughly, specifically how recrudescence, relapse, host susceptibility, and co-infections affect the various clinical scenarios as they relate to human infection.
To accomplish these goals, several different experimental plans have been designed, each of which is driven by the strategic infection, monitoring, collection, analysis, and integration of large, unique, 'omic' data sets in combination with hematological and clinical parameters of malaria. The MaHPIC is generating and combining unprecedented large host-pathogen datasets (i.e. from both the host and the pathogen) relating to malaria infection, metabolomics, immune profiling, functional genomics, epigenetics, proteomics and lipidomics, with the aid of informatics and computational modeling expertise.
These datasets, based on the non-human primate or human host and various Plasmodium species as pathogens, will help us better understand malaria as a disease in depth and pave the way for new preventive and therapeutic measures. We expect to provide a groundbreaking wealth of information that will address current challenges, with mathematical modeling and iterative experimentation being central to the efficiency and effectiveness of MaHPIC.
We are grateful for financial support and guidance from the National Institute of Allergy and Infectious Diseases (NIAID) and the opportunity for innovative discovery given this 5-year contract award, with the ultimate goal of publically releasing MaHPIC data so that many can benefit from continued mining of the data and discovery for years to come.
We are excited to be of service to scientists around the world, working to research, control, eliminate and ultimately eradicate malaria. The MaHPIC is timely in this regard. We are at the cusp of a new era in malaria research with unchartered territory and enormous possibilities. We welcome ideas for synergistic collaborations and funding opportunities to continue to grow this team effort, push the boundaries and achieve new heights.