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About MaHPIC

8 icons representing the MaHPIC cores

The MaHPIC team uses the comprehensive modern research approach called “systems biology” to study and catalog in molecular detail how malaria parasites interact with their human and  other animal hosts and cause disease. 

The MAHPIC team strives to deliver unique large datasets that hold potential for major breakthroughs that ultimately will advance our understanding of malaria and help diagnose, prevent or treat the disease. The MaHPIC has been innovative in its design of longitudinal infection studies, and using computational tools to integrate clinical, parasitological, functional genomics, proteomics, lipidomics and metabolomics data. The amout and types of malaria research data generated, integrated, and released for use by the broader scientific community has been unprecedented. (see data release updates and publications).

This research program involves clinical studies with human cohorts from many areas of the world, and nonhuman primate infections, all fundamental to developing and evaluating new malaria diagnostic tools, antimalarial drugs and vaccines for different types of malaria.  The central unifying hypothesis of this project has been that "Non-Human Primate host interactions with Plasmodium pathogens as model systems provided insights into mechanisms as well as indicators for human malarial disease conditions".

The Malaria Host-Pathogen Interaction Center (MaHPIC) was established in September 2012 by the National Institute of Allergy and Infectious Diseases, part of the US National Institutes of Health via a five-year contract award (see original press release and MaHPIC news, data releases, and publications).